8,128 research outputs found
The Changing Narratives of Death, Dying, and HIV in the United Kingdom
Death and infection were closely linked from the start of the HIV epidemic, until successful treatments became available. The initial impact of mostly young, gay men dying from HIV was powerful in shaping UK responses. Neoliberal discourses developed at the same time, particularly focusing on how citizens (rather than the state) should take responsibility to improve health. Subsequently âsuccessful ageingâ became an allied discourse, further marginalising death discussions. Our study reflected on a broad range of meanings around death within the historical UK epidemic, to examine how dying narratives shape contemporary HIV experiences. Fifty-one participants including people living with HIV, professionals, and activists were recruited for semistructured interviews. Assuming a symbolic interactionist framework, analysis highlighted how HIV deaths were initially experienced as not only traumatic but also energizing, leading to creativity. With effective antiretrovirals, dying changed shape (e.g., loss of death literacy), and better integration of palliative care was recommended
Investigating volumetric repainting to mitigate interplay effect on 4D robustly optimized lung cancer plans in pencil beam scanning proton therapy
Purpose: The interplay effect between dynamic pencil proton beams and motion of the lung tumor presents a challenge in treating lung cancer patients in pencil beam scanning (PBS) proton therapy. The main purpose of the current study was to investigate the interplay effect on the volumetric repainting lung plans with beam delivery in alternating order (âdownâ and âupâ directions), and explore the number of volumetric repaintings needed to achieve acceptable lung cancer PBS proton plan. Method: The current retrospective study included ten lung cancer patients. The total dose prescription to the clinical target volume (CTV) was 70 Gy(RBE) with a fractional dose of 2 Gy(RBE). All treatment plans were robustly optimized on all ten phases in the 4DCT data set. The Monte Carlo algorithm was used for the 4D robust optimization, as well as for the final dose calculation. The interplay effect was evaluated for both the nominal (i.e., without repainting) as well as volumetric repainting plans. The interplay evaluation was carried out for each of the ten different phases as the starting phases. Several dosimetric metrics were included to evaluate the worst-case scenario (WCS) and bandwidth based on the results obtained from treatment delivery starting in ten different breathing phases. Results: The number of repaintings needed to meet the criteria 1 (CR1) of target coverage (D95% â„ 98% and D99% â„ 97%) ranged from 2 to 10. The number of repaintings needed to meet the CR1 of maximum dose (ÎD1% \u3c 1.5%) ranged from 2 to 7. Similarly, the number of repaintings needed to meet CR1 of homogeneity index (ÎHI \u3c 0.03) ranged from 3 to 10. For the target coverage region, the number of repaintings needed to meet CR1 of bandwidth (\u3c100 cGy) ranged from 3 to 10, whereas for the high-dose region, the number of repaintings needed to meet CR1 of bandwidth (\u3c100 cGy) ranged from 1 to 7. Based on the overall plan evaluation criteria proposed in the current study, acceptable plans were achieved for nine patients, whereas one patient had acceptable plan with a minor deviation. Conclusion: The number of repaintings required to mitigate the interplay effect in PBS lung cancer (tumor motion \u3c 15 mm) was found to be highly patient dependent. For the volumetric repainting with an alternating order, a patient-specific interplay evaluation strategy must be adopted. Determining the optimal number of repaintings based on the bandwidth and WCS approach could mitigate the interplay effect in PBS lung cancer treatment
Impact of errors in spot size and spot position in robustly optimized pencil beam scanning proton-based stereotactic body radiation therapy (SBRT) lung plans
Purpose: The purpose of the current study was threefold: (a) investigate the impact of the variations (errors) in spot sizes in robustly optimized pencil beam scanning (PBS) proton-based stereotactic body radiation therapy (SBRT) lung plans, (b) evaluate the impact of spot sizes and position errors simultaneously, and (c) assess the overall effect of spot size and position errors occurring simultaneously in conjunction with either setup or range errors. Methods: In this retrospective study, computed tomography (CT) data set of five lung patients was selected. Treatment plans were regenerated for a total dose of 5000 cGy(RBE) in 5 fractions using a single-field optimization (SFO) technique. Monte Carlo was used for the plan optimization and final dose calculations. Nominal plans were normalized such that 99% of the clinical target volume (CTV) received the prescription dose. The analysis was divided into three groups. Group 1: The increasing and decreasing spot sizes were evaluated for ±10%, ±15%, and ±20% errors. Group 2: Errors in spot size and spot positions were evaluated simultaneously (spot size: ±10%; spot position: ±1 and ±2 mm). Group 3: Simulated plans from Group 2 were evaluated for the setup (±5 mm) and range (±3.5%) errors. Results: Group 1: For the spot size errors of ±10%, the average reduction in D99% for â10% and +10% errors was 0.7% and 1.1%, respectively. For â15% and +15% spot size errors, the average reduction in D99% was 1.4% and 1.9%, respectively. The average reduction in D99% was 2.1% for â20% error and 2.8% for +20% error. The hot spot evaluation showed that, for the same magnitude of error, the decreasing spot sizes resulted in a positive difference (hotter plan) when compared with the increasing spot sizes. Group 2: For a 10% increase in spot size in conjunction with a â1 mm (+1 mm) shift in spot position, the average reduction in D99% was 1.5% (1.8%). For a 10% decrease in spot size in conjunction with a â1 mm (+1 mm) shift in spot position, the reduction in D99% was 0.8% (0.9%). For the spot size errors of ±10% and spot position errors of ±2 mm, the average reduction in D99% was 2.4%. Group 3: Based on the results from 160 plans (4 plans for spot size [±10%] and position [±1 mm] errors Ă 8 scenarios Ă 5 patients), the average D99% was 4748 cGy(RBE) with the average reduction of 5.0%. The isocentric shift in the superiorâinferior direction yielded the least homogenous dose distributions inside the target volume. Conclusion: The increasing spot sizes resulted in decreased target coverage and dose homogeneity. Similarly, the decreasing spot sizes led to a loss of target coverage, overdosage, and degradation of dose homogeneity. The addition of spot size and position errors to plan robustness parameters (setup and range uncertainties) increased the target coverage loss and decreased the dose homogeneity
Accurate prediction of gene feedback circuit behavior from component properties
A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we used timeâlapse fluorescence microscopy to quantitatively analyze two autoregulatory negative feedback circuits. By measuring the gene regulation functions of the corresponding repressorâpromoter interactions, we accurately predicted the expression level of the autoregulatory feedback loops, in molecular units. This demonstration that quantitative characterization of regulatory elements can predict the behavior of genetic circuits supports a fundamental requirement of synthetic biology
Lattice density-functional theory of surface melting: the effect of a square-gradient correction
I use the method of classical density-functional theory in the
weighted-density approximation of Tarazona to investigate the phase diagram and
the interface structure of a two-dimensional lattice-gas model with three
phases -- vapour, liquid, and triangular solid. While a straightforward
mean-field treatment of the interparticle attraction is unable to give a stable
liquid phase, the correct phase diagram is obtained when including a suitably
chosen square-gradient term in the system grand potential. Taken this theory
for granted, I further examine the structure of the solid-vapour interface as
the triple point is approached from low temperature. Surprisingly, a novel
phase (rather than the liquid) is found to grow at the interface, exhibiting an
unusually long modulation along the interface normal. The conventional
surface-melting behaviour is recovered only by artificially restricting the
symmetries being available to the density field.Comment: 16 pages, 6 figure
A new approach to the inverse problem for current mapping in thin-film superconductors
A novel mathematical approach has been developed to complete the inversion of
the Biot-Savart law in one- and two-dimensional cases from measurements of the
perpendicular component of the magnetic field using the well-developed
Magneto-Optical Imaging technique. Our approach, especially in the 2D case, is
provided in great detail to allow a straightforward implementation as opposed
to those found in the literature. Our new approach also refines our previous
results for the 1D case [Johansen et al., Phys. Rev. B 54, 16264 (1996)], and
streamlines the method developed by Jooss et al. [Physica C 299, 215 (1998)]
deemed as the most accurate if compared to that of Roth et al. [J. Appl. Phys.
65, 361 (1989)]. We also verify and streamline the iterative technique, which
was developed following Laviano et al. [Supercond. Sci. Technol. 16, 71 (2002)]
to account for in-plane magnetic fields caused by the bending of the applied
magnetic field due to the demagnetising effect. After testing on
magneto-optical images of a high quality YBa2Cu3O7 superconducting thin film,
we show that the procedure employed is effective
Density Functional for Anisotropic Fluids
We propose a density functional for anisotropic fluids of hard body
particles. It interpolates between the well-established geometrically based
Rosenfeld functional for hard spheres and the Onsager functional for elongated
rods. We test the new approach by calculating the location of the the
nematic-isotropic transition in systems of hard spherocylinders and hard
ellipsoids. The results are compared with existing simulation data. Our
functional predicts the location of the transition much more accurately than
the Onsager functional, and almost as good as the theory by Parsons and Lee. We
argue that it might be suited to study inhomogeneous systems.Comment: To appear in J. Physics: Condensed Matte
Depletion potential in hard-sphere mixtures: theory and applications
We present a versatile density functional approach (DFT) for calculating the
depletion potential in general fluid mixtures. In contrast to brute force DFT,
our approach requires only the equilibrium density profile of the small
particles {\em before} the big (test) particle is inserted. For a big particle
near a planar wall or a cylinder or another fixed big particle the relevant
density profiles are functions of a single variable, which avoids the numerical
complications inherent in brute force DFT. We implement our approach for
additive hard-sphere mixtures. By investigating the depletion potential for
high size asymmetries we assess the regime of validity of the well-known
Derjaguin approximation for hard-sphere mixtures and argue that this fails. We
provide an accurate parametrization of the depletion potential in hard-sphere
fluids which should be useful for effective Hamiltonian studies of phase
behavior and colloid structure
Entropic torque
Quantitative predictions are presented of a depletion-induced torque and
force acting on a single colloidal hard rod immersed in a solvent of hard
spheres close to a planar hard wall. This torque and force, which are entirely
of entropic origin, may play an important role for the key-lock principle,
where a biological macromolecule (the key) is only functional in a particular
orientation with respect to a cavity (the lock)
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